GASTROINTESTINAL PATHOGEN PANEL

The Problem:

Acute gastroenteritis (AGE; defined as diarrhea or vomiting) is a major cause of illness in the United States.  AGE is caused by a variety of viral, bacterial, and parasitic pathogens among other noninfectious causes.  Each year, 31 major known pathogens acquired in the United States caused an estimated 9.4 million episodes of foodborne illness.  One of the dangers of food poisoning and gastroenteritis is the loss of fluids resulting from diarrhea and vomiting, which can lead to dehydration.  Accurate detection of the causative agent is important.

A New Tool in the Fight Against Food Poisoning and Acute Gastroenteritis:

MicroPathID – Gastrointestinal Pathogen Panel (GPP)Uses real-time PCR to identify the 17 viral, bacterial and parasitic species associated with gastroenteritis.

Detect and identify 90% of the causative bacterial, viral and parasitic agents of gastroenteritis.

Bacteria


Campylobacter spp.
Clostridium difficile
E. coli O157
Enteroaggregative E. coli (EAEC)
Enterotoxigenic E. coli (ETEC)
Salmonella spp.
Shigella/Enteroinvasive E. coli (EIEC)
Shiga toxin producing E. coli
Vibrio parahaemolyticus
Vibrio spp.
Yersinia enterocolitica

Viruses


Adenovirus 40/41
Norovirus GI/GII
Rotavirus A

Parasites


Cryptosporidium spp.
Entamoeba histolytica
Giardia lamblia / G. intestinalis

Better detection equals more confidence

Conventional Cultures:

  • Are unable to produce growth in certain pathogens
  • Require 48-72 hours for results

Clinical Advantages:  MicroPathID – GPP Panel

  • Simplified testing: 1 sample, 1 test, 17 pathogens
  • Rapid PCR results on pathogen identification
    • 12 – 24 hours from specimen receipt
  • Improved Sensitivity
    • 3-5X more sensitive than conventional culture
    • 99.9% Sensitivity and 97% Specificity
  • Can detect polymicrobial infections
  • Unaffected by concurrent antibiotic use

Multiple specimen collection options for patient and practice convenience.

The Gastrointestinal Pathogen Panel is performed by GI Pathology from home collected fresh stool or fecal swab or a physician collected rectal swab.

References:
1 Scallan E, Griffin PM, Angulo FJ, Tauxe RV, Hoekstra RM. Foodborne illness acquired in the United States—unspecified agents.Emerg Infect Dis. 2011;17:16–22.

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