Infectious complications after transrectal ultrasound–guided prostate biopsy (TRUSPB) have increased in recent years.
Fecal carriage of fluoroquinolone-resistant E. coli strains is an important risk factor for infectious complications after TRUSPB. In addition, the incidence of ESBL-producing bacteria has increased in many countries. Many ESBL-producing bacteria are resistant not only to penicillins and cephalosporins, but also to fluoroquinolones and aminoglycosides. This underscores the need to find new strategies to fight this problem.
A New Tool in the Fight Against Post-TRUSPB Complications:
MicroPathID – Pre-Prostate Biopsy Panel (PBx) – Provides rapid molecular identification of 17 pathogenic bacteria and fungal species associated with potential infectious complications following TRUSPB and detection of up to 36 genes that confer antibiotic resistance across 10 drug classes. Confirmatory culture and susceptibility results are provided to help guide antibiotic selection and assist with antimicrobial stewardship.
Rapid PCR Detection
17 Pathogenic Bacteria
and Fungal Species
Rapid PCR Detection
36 Gene Antibiotic
~10 Drug Classes
AmpC beta lactamase
Extended Spectrum Betalactamase
Macrolides, lincosamides, streptogramins
- Are unable to produce growth in certain pathogens
- Require 48-72 hours for results
Clinical Advantages: MicroPathID – PBx Panel
- Rapid PCR results on pathogen identification and antibiotic resistance
- 12 – 24 hours from specimen receipt
- Improved Sensitivity
- 3-5X more sensitive than conventional culture
- Can detect polymicrobial infections
- Unaffected by concurrent antibiotic use
- Culture confirmation and susceptibility
- Phenotypic characterization combined with genotypic information for improved outcomes
The PBx Panel is performed by Bostwick Laboratories from a rectal swab specimen collected prior to administration of prophylactic antibiotics.
Collect rectal swab specimen
Specimen arrives at Bostwick Laboratories – PCR testing and cultures begin
Receive PCR results of 17 pathogens and Antibiotic Resistance Genes
Receive confirmatory culture and susceptibility results
Informed prophylaxis antibiotic selection