VAGINAL PATHOGEN PANEL

Clinical Background:

Vaginitis is one of the most common reasons women seek gynecologic care. However, a wide variety of pathogens can cause vaginitis, making definitive diagnosis and treatment difficult.

Bacterial vaginosis (BV) is caused by an overgrowth of anaerobic bacteria in the vagina, leading to depletion of the normally protective lactobacilli. BV is associated with an increased risk of acquiring sexually transmitted infections, including HIV, as well as with pregnancy complications.

Other causes of vaginitis include aerobic vaginitis (AV), vaginal candidiasis (VC), and sexually transmitted infections (STI).

Since many of the bacteria associated with vaginitis are either difficult to culture or have not previously been cultured, the use of molecular diagnostic techniques to detect these pathogens is critical.

Technology:

MicroPathID uses real-time PCR to identify and quantify up to 25 varieties of bacteria, yeast, and parasites that may be the cause of vaginitis. This methodology is more sensitive than conventional culture in detecting pathogens.

Clinical Advantages:

  • Simultaneously identifies bacteria, yeast, and parasites.
  • Detects up to 25 microorganisms with just one swab.
  • Can detect polymicrobial infections.
  • Detects pathogens that cannot be cultured.
  • Unaffected by concurrent antibiotic use.

Bacterial Vaginosis Panel


Women’s Health Laboratories’ BV panel detects up to 12 bacteria that may be present in the vaginal microflora. The semi-quantitative results and relative abundance are put into an algorithm to help the physician determine whether BV is the cause of the patient’s symptoms.

Atopobium vaginae
BVAB2
Gardnerella vaginalis
Lactobacillus crispatus
Lactobacillus gasseri
Lactobacillus jensenii
Lactobacillus iners
Megasphaera 1
Prevotella bivia
Mobiluncus curtisii
Mycoplasma hominis
Ureaplasma urealyticum

Aerobic Vaginitis Panel


MicroPathID tests for the 4 most common causes of AV.

Enterococcus faecalis
Escherichia coli
Streptococcus agalactiae (Group B)
Staphylococcus aureus

Sexually Transmitted Infections Panel


MicroPathID tests for 4 common STI pathogens.

Chlamydia trachomatis
Neisseria gonorrhoeae
Trichomonas vaginalis
Mycoplasma genitalium

Candida Panel


While typically caused by Candida albicans, other Candida species have also been identified as causative agents of VC. MicroPathID tests for 5 Candida species.

Candida albicans
Candida glabrata
Candida tropicalis
Candida parapsilosis
Candida krusei

Lesion Panel


The Lesion Panel helps determine the cause of a patient’s active lesion.

HSV–1
HSV–2
Treponema pallidum

Separate swab required for lesion panel

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